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基本情報
| 氏名（漢字） |
斎藤 芳郎 |
| 氏名（カナ） |
サイトウ ヨシロウ |
| 氏名（ローマ字） |
SAITO Yoshiro |
| 性別 |
男 |
| 生年月日 |
1973/02/03 |
| 研究室 |
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| 研究室電話番号 |
0774-65-6258 |
| 研究室ＦＡＸ番号 |
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| メールアドレス |
ysaito@mail.doshisha.ac.jp |
1995-2001 血漿セレン含有タンパク質selenoprotein Pの構造と機能に関する研究に従事
2002-2008 生体のストレスシグナルに関する研究に従事
2001-2002 日本学術振興会特別研究員ＤＣ２（北海道大学大学院薬学研究科）
2002-2007 産業技術総合研究所若手任期付研究員
2007-2008 産業技術総合研究所パーマネント研究員
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- 6.Production and Application of Monoclonal Antibodies to Human Selenoprotein P. 斎藤 芳郎 Journal of Health Science 47 346-352 2001
- 7.A Comparative Study on the Hydroperoxide and Thiol Specificity of the Glutathione Peroxidase Family and Selenoprotein P. 斎藤 芳郎 Journal of Biological Chemistry 277 41254-41258 2002
- 8.Characterization of Selenoprotein P as a Selenium Supply Protein. 斎藤 芳郎 European Journal of Biochemistry 269 5746-5751 2002
- 9.Identification of Selenoprotein P as a Cell-Death Inhibitory Factor 斎藤 芳郎 Biological and Pharmaceutical Bulletin 26 794-798 2003
- 10.Cell Death Caused by Selenium Deficiency and Protective Effect of Antioxidants 斎藤 芳郎 Journal of Biological Chemistry 278 39428-39434 2003
- 11.DJ-1 Has a Role in Antioxidative Stress to Prevent Cell Death 斎藤 芳郎 EMBO Report 5 213-218 2004
- 12.Application of Water-Soluble Radical Initiator, 2,2'-Azobis [2-(2-imidazolin-2-yl)propane] Dihydrochloride, to a Study of Oxidative Stress 斎藤 芳郎 Free Radical Research 38 375-384 2004
- 13.Effects of a Novel Gaseous Antioxidative System Containing a Rosemary Extract on the Oxidation Induced by Nitrogen Dioxide and Ultraviolet Radiation 斎藤 芳郎 Bioscience, Biotechnology, and Biochemistry 68 781-786 2004
- 14.Effects of Volatile Constituents of the Rosemary Extract on the Oxidation Caused by Ultraviolet Radiation and Nitrogen Dioxide 斎藤 芳郎 Aroma Research 18 118-122 2004
- 15.Domain structure of bi-functional selenoprotein P 斎藤 芳郎 Biochemical Journal 381 841-846 2004
- 16.Selenoprotein P, as a Predictor for Evaluating Gemcitabine Resistance in Human Pancreatic Cancer Cells 斎藤 芳郎 International Journal of Cancer 112 184-189 2004
- 17.Characterization of Cellular Uptake and Distribution of Vitamin E 斎藤 芳郎 Annals of the New York Academy of Sciences 1031 368-375 2004
- 18.トコトリエノールのストレス抑制作用と細胞内取り込みについて 斎藤 芳郎 ビタミンE研究の進歩 11 108-114 2004
- 19.Characterization of monochloramine toxicity on PC12 cells and protective effect of tocopherol via antioxidative function 斎藤 芳郎 Archives of Biochemistry and Biophysics 436 101-109 2005
- 20.Cytotoxic effect of formaldehyde with free radicals via increment of cellular reactive oxygen species 斎藤 芳郎 Toxicology 210 235-245 2005
- 21.Adaptation to hydrogen peroxide enhances PC12 cell tolerance against oxidative damage 斎藤 芳郎 Neuroscience Letters 383 256-259 2005
- 22.Proteomic characterization of oxidative dysfunction in human umbilical vein endothelial cells (HUVEC) induced by exposure to oxidized LDL 斎藤 芳郎 Free Radical Research 39 1335-1344 2005
- 23.4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2 斎藤 芳郎 Journal of Biological Chemistry 280 41921-41927 2005
- 24.Lipid peroxidation: Mechanisms, inhibition, and biological effects. 斎藤 芳郎 Biochemical and Biophysical Research Communications 338 668-676 2005
- 25.必須微量元素セレン及び酸化ストレスに伴う細胞死に対するAOBの添加効果 斎藤 芳郎 AOB研究会 4 42-46 2005
- 26.Domain Structure of Bi-functional Selenoprotein P. 斎藤 芳郎 Natural Antioxidants and Micronutrients 105-108 2005
- 27.Adaptive response induced by lipid peroxidation products in cell cultures 斎藤 芳郎 FEBS Letters 580 479-483 2006
- 28.Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta12,14-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms 斎藤 芳郎 Journal of Biological Chemistry 281 14440-14445 2006
- 29.Turning point in apoptosis/necrosis induced by hydrogen peroxide 斎藤 芳郎 Free Radical Research 40 619-630 2006
- 30.酸化ストレスから体を守るミネラル“セレン” 斎藤 芳郎 バイオサイエンスとインダストリー 64 159-160 2006
- 31.抗酸化蛋白質DJ-1の酸化修飾による機能制御 斎藤 芳郎 蛋白質の翻訳後修飾と疾患プロテオミクス 34-40 2006
- 32.Cytotoxic effects of various stressors on PC12 cells: Involvement of oxidative stress and effect of antioxidants 斎藤 芳郎 NeuroToxicology 28 67-75 2007
- 33.Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells- INVOLVEMENT OF HYDROGEN PEROXIDE-DEPENDENT AND -INDEPENDENT ACTION 斎藤 芳郎 Free Radical Biology and Medicine 42 675-685 2007
- 34.Levels of Lipid Peroxidation in Human Plasma and Erythrocytes: Comparison between Fatty Acids and Cholesterol 斎藤 芳郎 Lipids 42 439-449 2007
- 35.Protective effects of 15-deoxy-D12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: Induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione 斎藤 芳郎 Journal of Neurochemistry 102 1625-1634 2007
- 36.Hydroxyoctadecadienoic acid and oxidatively modified peroxiredoxins in the blood of Alzheimer's disease patients and their potential as biomarkers 斎藤 芳郎 Neurobiology of Aging 30 174-185 2009
- 37.Cholesterol is more susceptible to oxidation than linoleates in cultured cells under oxidative stress induced by selenium deficiency and free radicals 斎藤 芳郎 FEBS Letters 581 4349-4354 2007
- 38.Chemical Reactivities and Physical Effects in Comparison between Tocopherols and Tocotrienols. 斎藤 芳郎 Journal of Bioscience and Bioengineering 104 439-445 2007
- 39.ストレスに対する生体の応答 蛋白質 斎藤 芳郎 ストレスの科学と健康 52-59 2007
- 40.Antioxidant capacity of BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran, and uric acid as evaluated by ORAC method and inhibition of lipid peroxidation 斎藤 芳郎 Bioorganic & Medicinal Chemistry Letters 18 2464-2466 2008
- 41.Simple Assessment of Radical Scavenging Capacity of Beverages 斎藤 芳郎 Journal of Agricultural Food Chemistry 56 3386-3390 2008
- 42.Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells 斎藤 芳郎 Journal of Nutritional Biochemistry, in press 20 350-357 2008
- 43.Effect of Oxygen Concentration on Free Radical-Induced Cytotoxicity 斎藤 芳郎 Bioscience Biotechnology and Biochemistry 72 1491-1497 2008
- 44.Regulation of GCL Activity and Cellular Glutathione through Inhibition of ERK Phosphorylation 斎藤 芳郎 BioFactors 33 1-11 2008
- 45.γ-Tocopheryl quinone, not α-tocopheryl quinone, induces adaptive response through up-regulation of cellular glutathione and cysteine availability via activation of ATF4 斎藤 芳郎 Free Radical Research 42 674-687 2008
- 46.Assessment of antioxidative activity of extract from fermented grain food mixture using chemical and cellular systems 斎藤 芳郎 BioFactors 31 237-248 2008
- 47.Assessment of antioxidant capacity of fermented grain food product, Antioxidant Biofactor (AOB), by using pyranine and pyrogallol red as a combined probe 斎藤 芳郎 Food Chemistry 114 429-433 2008
- 48.Assessment of Radical Scavenging Capacity and Lipid Peroxidation Inhibiting Capacity of Antioxidant 斎藤 芳郎 Journal of Agricultural Food Chemistry 56 8255-8260 2008
- 49.Induction of adaptive response and enhancement of PC12 cell tolerance by lipopolysaccharide primarily through the upregulation of glutathione S-transferase A3 via Nrf2 activation 斎藤 芳郎 Free Radical Biology and Medicine 45 1437-1445 2008
- 50.The role of α-tocopherol in hypofunction of activity with aging in α-tocopherol transfer protein knockout mice as assessed by oxidative stress biomarkers 斎藤 芳郎 Journal of Nutritional Biochemistry 21 66-76 2009
- 51.Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults 斎藤 芳郎 Bioorganic & Medicinal Chemistry 16 10332-10337 2008
- 52.Novel finding regarding cholesterol oxidation: Cholesterol is more susceptible to oxidation than linoleates in cultured cells under oxidative stress. 斎藤 芳郎 International Arteriosclerosis Society (IAS) commentaries 2008
- 53.血漿セレン含有蛋白質セレノプロテインPに関する最近の話題 斎藤 芳郎 ビタミン 83 662-665 2009
- 54.Antioxidant action of sugar-pendant C(60) fullerenes. 斎藤 芳郎 Bioorganic & Medicinal Chemistry Letters 19 5902-5904 2009
- 55.Assessment of antioxidant capacity of fermented grain food product, Antioxidant Biofactor (AOB), by ORAC method and inhibition of lipid peroxidation 斎藤 芳郎 Food Chemistry 114 429-433 2009
- 56.Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients. 斎藤 芳郎 Neuroscience Letters 465 1-5 2009
- 57.Sustainable and practical degradation of intact chicken feathers by cultivating a newly isolated thermophilic Meiothermus ruber H328 斎藤 芳郎 Applied Microbiology and Biotechnology 82 841-850 2009
- 58.Protein Adsorption of Ultrafine Metal Oxide and Its Influence on Cytotoxicity toward Cultured Cells 斎藤 芳郎 Chemical Research in Toxicology 22 543-553 2009
- 59.Hydroxyoctadecadienoic acid as a potential biomarker for oxidative stress in patients with chronic hepatitis C 斎藤 芳郎 Journal of Gastroenterology and Hepatology, 25 107-115 2009
- 60.Action of 6-amino-3-pyridinols as novel antioxidants against free radicals and oxidative stress in solution, plasma, and cultured cells. 斎藤 芳郎 Free Radical Biology and Medicine 48 1358-1365 2010
- 61.Proteomic characterization of the striatum and midbrain treated with 6-hydroxydopamine: Alteration of 58-kDa glucose-regulated protein and C/EBP homologous protein. 斎藤 芳郎 Free Radical Research 44 410-421 2010
- 62.脂質酸化物により誘導される適応反応のメカニズム 斎藤 芳郎 放射線生物研究 45 2 160-169 2010
- 63.Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals 斎藤 芳郎 Neuroscience Letters 483 201-205 2010
- 64.Cytoprotective effect of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function. 斎藤 芳郎 Free Radical Biology and Medicine 49 1542-1549 2010
- 65.A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance. 斎藤 芳郎 Cell Metabolism 12 483-495 2010
- 66.Selenoprotein-P is down-regulated in prostate cancer, which results in lack of protection against oxidative damage. 斎藤 芳郎 The Prostate 71 824-834 2010
- 67.Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity. 斎藤 芳郎 Free Radical Research 45 3 342-350 2010
- 68.Correlation between saliva cortisol concentration and sympathovagal balance before sleep in young male subjects. 斎藤 芳郎 Stress Science Research 26 48-52 2011
- 69.Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. 斎藤 芳郎 Gene to Cells 16 692-703 2011
- 70.alpha-Tocopheryl Phosphate: Uptake, Hydrolysis, and Antioxidant Action in Cultured Cells and Mouse. 斎藤 芳郎 Free Radical Biology and Medicine 50 1794-1800 2011
- 71.24(S)-Hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. 斎藤 芳郎 Journal of Biological Chemistry 286 24666-24673 2011
- 72.Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione. 斎藤 芳郎 PLoS ONE 6 e27883 2011
- 73.Cytoprotective effects of geraniin against peroxynitrite- and peroxyl radical-induced cell death via free radical scavenging activity. 斎藤 芳郎 Food Chemistry 132 1899-1907 2012
- 74.Novel compound heterozygous mutations in the SBP2 gene: characteristic clinical manifestations and the implications of GH and triiodothyronine in longitudinal bone growth and maturation. 斎藤 芳郎 European Journal of Endocrinology 166 757-764 2012
- 75.Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes. Yoshiro Saito PLoS ONE 7 e34952 2012
- 76.A novel fluorescent probe with high sensitivity and selective detection of lipid hydroperoxides in cells. 斎藤芳郎 RSC Advances 2 7894-7900 2012
- 77.Serum selenium and selenoprotein P in patients with silicosis 斎藤芳郎 Journal of Trace Elements in Medicine and Biology 27 40-44 2013
- 78.Enhanced CD36 expression changes the role of Nrf2 activation from anti-atherogenic to pro-atherogenic in apoE-deficient mice. 斎藤芳郎 Atherosclerosis 225 83-9 2013
- 79.Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner. 斎藤芳郎 Molecular and Cellular Biology 33 340-359 2013
- 80.パーキンソン病におけるバイオマーカーの現状—マイケルＪフォックス財団の取り組み 斎藤芳郎 ファルマシア 49 9 870-872 2013
- 81.Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death. Akishi Okabe, Yasuomi Urano, Sayoko Itoh, Naoto Suda, Rina Kotani, Yuki Nishimura, Yoshiro Saito, and Noriko Noguchi Redox Biology 2 28-35 2014
- 82.トコフェロール・トコトリエノールによる抗酸化作用を介した神経保護効果 ビタミンE研究の進歩 15 73-79 2012
- 83.LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance. Diabetes 63 1649-1664 2014
- 84.The significance of oxidized DJ-1 protein (oxDJ-1) as a biomarker for Parkinson’s disease. Brain and Nerve 66 471-477 2014
- 85.7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: Difference between cellular and plasma lipid peroxidation. Biochemical and Biophysical Research Communications 446 741-744
- 86.Oxidized DJ-1 as a possible biomarker of Parkinson’s disease. 斎藤芳郎 Journal of Clinical Biochemistry and Nutrition 49 870-872 2013
- 87.Diverse functions of 24(S)-hydroxycholesterol in the brain. Biochemical and Biophysical Research Communications 446 692-696 2014
- 88.Immunostaining of oxidized DJ-1 in human and mouse brain. 斎藤芳郎 Journal of Neuropathology and Experimental Neurology 73 714-728 2014
- 89.Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells. Diabetologia 57 1968-1976 2014
- 90.Development of a sol particle homogeneous immunoassay for measuring full-length selenoprotein P in human serum. Journal of Clinical Laboratory Analysis 2015
- 91.24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8. Steloids 99 230-237 2015
- 92.Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene. 斎藤芳郎 Journal of Lipid Research 56 2172-2182 2015
- 93.The protective role of DJ-1 in ultraviolet-induced damage of human skin: DJ-1 levels in the stratum corneum as an indicator of antioxidative defense. Archives of Dermatological Research 307 925-935 2015
- 94.New aspects of 24S-hydroxycholesterol in modulating neuronal cell death. Free Radical Biology & Medicine 87 366-372 2015
- 95.Effects of vitamin E on 24(S)-hydroxycholesterol-induced apoptosis and necroptosis. Journal of Steroid Biochemistry and Molecular Biology 2016
- 96.Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patients. 斎藤芳郎 Scientific Reports 6 30793 2016
- 97.Oxidized Lipoprotein as a Major Vessel Cell Proliferator in Oxidized Human Serum. 斎藤芳郎 PLoS ONE 11 e0160530 2016
- 98.Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox. 斎藤芳郎 Scientific Reports 7 43441 2017
- 99.Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of ROS and AMPK in muscle. 斎藤芳郎 Nature Medicine 23 508-516 2017
- 100.セレンの生物学—セレノプロテインの機能と疾患 斎藤芳郎 細胞工学 35 240-246 2016
- 101.A Gene Expression Profiling Approach to Study the Influence of Ultrafine Particles on Rat Lungs. Katsuhide Fujita, Yasuo Morimoto, Akira Ogami, Isamu Tanaka, Shigehisa Endoh, Kunio Uchida, Hiroaki Tao, Mikio Akasaka, Masaharu Inada, Kazuhiro Yamamoto, Hiroko Fukui, Mieko Hayakawa, Masanori Horie, Yoshiro Saito, Yasukazu Yoshida, Hitoshi Iwahashi, Etsuo Niki and Junko Nakanishi Atmospheric and Biological Environmental Monitoring 219-227 2009
- 102.グルタミン酸誘導性の神経細胞死に対するビタミンE類の抑制効果 斎藤芳郎、西尾敬子、赤澤（小川）陽子、吉田康一、野口範子、二木鋭雄 ビタミンE研究の進歩 14 27-32 2010
- 103.Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox. Bharatwaj Sowrirajan, Yoshiro Saito, Deepak Poudyal, Qian Chen, Hongyan Sui, Suk See DeRavin, Hiromi Imamichi, Toyotaka Sato, Douglas B. Kuhns, Noriko Noguchi, Harry L. Malech, H. Clifford Lane and Tomozumi Imamichi Scientific Reports 7 43441 2017
- 104.Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of ROS and AMPK in muscle. Hirofumi Misu, Hiroaki Takayama，Yoshiro Saito, Yuichiro Mita, Akihiro Kikuchi, Kiyo-aki Ishii, Keita Chikamoto, Takehiro Kanamori, Natsumi Tajima, Fei LanLan, Yumie Takeshita, Masao Honda, Mutsumi Tanaka, Seiji Kato, Naoto Matsuyama, Yuya Yoshioka, Kaito Iwayama, Kumpei Tokuyama, Nobuhiko Akazawa, Seiji Maeda, Kazuhiro Takekoshi, Seiichi Matsugo, Noriko Noguchi, Shuichi Kaneko, and Toshinari Takamura Nature Medicine 23 508-516 2017
- 105.Eicosapentaenoic Acid Downregulates Expression of the Selenoprotein P Gene by Inhibiting Sterol regulatory element-binding protein-1c Independently of the AMP-activated protein kinase Pathway in H4IIEC3 Hepatocytes. Natsumi Tajima-Shirasaki, Kiyo-aki Ishii, Hiroaki Takayama, Takayoshi Shirasaki, Hisakazu Iwama, Keita Chikamoto, Yoshiro Saito, Yasumasa Iwasaki, Atsushi Teraguchi, Fei Lan, Akihiro Kikuchi, Yumie Takeshita, Koji Murao, Seiichi Matsugo, Shuichi Kaneko, Hirofumi Misu, and Toshinari Takamura Journal of Biological Chemistry 292 10791-800 2017
- 106.Diagnosis of Parkinson's disease and the level of oxidized DJ-1 protein. Yuko Yamagishi, Kazumasa Saigoh, Yoshiro Saito, Ikuko Ogawa, Yoshiyuki Mitsui, Yoshiyuki Hamada, Makoto Samukawa, Hidekazu Suzuki, Motoi Kuwahara, Makito Hirano, Noriko Noguchi, Susumu Kusunoki Neuroscience Research 2017
- 107.Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models. Yuichiro Mita, Kaho Nakayama, Shogo Inari, Yukina Nishito, Yuya Yoshioka, Naoko Sakai, Kanade Sotani, Takahiro Nagamura, Yuki Kuzuhara, Kumi Inagaki, Miki Iwasaki, Hirofumi Misu, Masaya Ikegawa, Toshinari Takamura, Noriko Noguchi, and Yoshiro Saito Nature Communications 2017
- 108.The pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy. Kentaro Shimasaki, Miho Watanabe-Takahashi, Masato Umeda, Satoru Funamoto, Yoshiro Saito, Noriko Noguchi, Keigo Kumagai, Kentaro Hanada, Fujiko Tsukahara, Yoshiro Maru, Norihito Shibata, Mikihiko Naito, Kiyotaka Nishikawa Gene to Cells 2017
- 1.Hirofumi Misu, Hiroaki Takayama，Yoshiro Saito, Yuichiro Mita, Akihiro Kikuchi, Kiyo-aki Ishii, Keita Chikamoto, Takehiro Kanamori, Natsumi Tajima, Fei LanLan, Yumie Takeshita, Masao Honda, Mutsumi Tanaka, Seiji Kato, Naoto Matsuyama, Yuya Yoshioka, Kaito Iwayama, Kumpei Tokuyama, Nobuhiko Akazawa, Seiji Maeda, Kazuhiro Takekoshi, Seiichi Matsugo, Noriko Noguchi, Shuichi Kaneko, Toshinari Takamura 基盤研究（Ｂ）（一般） 2017
- 2.血漿セレン含有タンパク質セレノプロテインPの機能と生理的意義の解析 特別研究員奨励費 2000
- 3.酸化血清中に存在する細胞傷害因子の探索-新規酸化ストレスマーカーの同定を目指して 若手研究（Ｂ） 2004
- 4.培養神経細胞および幼若ラット脳を用いたドーパミン神経障害メカニズムの探究 若手研究（Ｂ） 2006
- 5.新規バイオマーカー酸化DJ-1を用いたパーキンソン病の早期診断・早期治療法の開発 萌芽研究 2013
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